clock-drawing-test, a measure of cognitive decline in Alzheimer patients

Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice
Michael W. Marlatta,b, Paul J. Lucassena, Henriette van Praagb
Brainresearch 1941 (2010) 93 99

Chronic sleep restriction causes a decrease in hippocampal volume in adolescent rats, which is not explained by changes in glucocorticoid levels or neurogenesis
A. NOVATI,a H. J. HULSHOF,b J. M. KOOLHAAS,a P. J. LUCASSENc AND P. MEERLOa
Neuroscience (2011), article in press

Early maternal deprivation affects dentate gyrus structure and emotional learning in adult female rats
Charlotte A. Oomen & Heleen Soeters & Nathalie Audureau & Lisa Vermunt & Felisa N. van Hasselt & Erik M. M. Manders & Marian Jols & Harm Krugers & Paul J. Lucassen
Psychopharmacology (2011) 214:249260, DOI 10.1007/s00213-010-1922-8

Hippocampal GR expression is increased in elderly depressed females
Q. Wanga, M. Joelsa,b, D.F. Swaabc, P.J. Lucassena
Neuropharmacology 62 (2012) 527 - 533

Accumulation of intraneuronal beta-amyloid correlates with ApoE4 genotype
Christensen D, Schneider-Axmann T, Lucassen P, Bayer TA, Wirths O (2010)
Acta Neuropathol.2010, 119:555–566

The histone deacetylase inhibitor valproic acid inhibits cancer cell proliferation via down-regulation of the Alzheimer amyloid precursor protein.
Venkataramani V, Rossner C, Iffland L, Schweyer S, Tamboli I, Walter J, Wirths O, Bayer TA.
J Biol Chem. 2010 Feb 9. [Epub ahead of print]

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain.
Hartlage-Rübesamen M, Staffa K, Waniek A, Wermann M, Hoffmann T, Cynis H, Schilling St, Demuth H-U, Rößner St.
Int. J. of Dev. Neurosci. 2009, 27, 835-835

Heterologous Expression and Characterization of Mammalian Glutaminyl Cyclase Isoenzymes.
Stephan A, Wermann M, von Bohlen A, Koch B, Cynis H, Demuth H-U, Schilling St.
FEBS-Journal 2009, 276, 6522–6536

APP/PS1KI bigenic mice develop early synaptic deficits and hippocampus atrophy.
Breyhan H, Wirths O, Duan K, Marcello A, Rettig J, Bayer TA
2009 Acta Neuropathol. 117:677–685.

Circulating immune complexes of Abeta and IgM in plasma of patients with Alzheimer’s disease.
Marcello A, Wirths O, Schneider-Axmann T, Degerman-Gunnarson M, Lannfelt L, Bayer TA
2009 J Neural Transm. 116:913–20.

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model.
Wirths O, Breyhan H, Cynis H, Schilling S, Demuth H-U, Bayer TA
2009 Acta Neuropathol. 118:487–496

Formic acid is essential for immunohistochemical detection of aggregated intraneuronal Aβ peptides in mouse models of Alzheimer’s disease.
Christensen DZ, Bayer TA, Wirths O
2009 Brain Res 13 1:116–125

Pyroglutamate Abeta pathology in APP/PS1KI mice, sporadic and familial Alzheimer’s disease
Wirths O, Bethge T, Marcello A, Harmeier A, Jawahr S, Lucassen PJ, Multhaup G, Brody D, Esparza T, Ingelsson M, Kalimo H, Lannfelt L, Bayer TA (2010)
cases. J Neural Transm (2010) 117:85–96

Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Aβ in plasma of patients with Alzheimer’s disease.
Marcello A, Wirths O, Schneider-Axmann T, Degerman-Gunnarsson M, Lannfelt L, Bayer TA
Neurobiol Aging, 10.1016/j.neurobiolaging.2009.08.011

pGlu-Amyloid Peptide Formation is Mediated by Glutaminyl Cyclase in Mammalian Cells: Implications For a New Treatment Strategy for Alzheimer's Disease
Cynis H, Scheel E, Saido TC, Schilling St and Demuth H-U.
Biochemistry 2008, 47, 7405-7413

Changes in adult neurogenesis in neurodegenerative diseases; cause or consequence?
Alyssa Thompson, Karin Boekhoorn, Anne-Marie Van Dam, and Paul J Lucassen.
Genes, Brain and Behaviour, 7 (Suppl. 1), 28–42, 2008.

Alzheimer’s Disease: Cerebrovascular Dysfunction, Oxidative stress, and Advanced Clinical Therapies.
Michael W. Marlatt, Paul J. Lucassen, George Perry, Mark A. Smith and Xiongwei Zhu.
Journal of Alzheimer’s Disease vol 15, 199–210, 2008.

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.
Zabrocki P, Bastiaens I, Delay C, Bammens T, Ghillebert R, Pellens K, De Virgilio C, Van Leuven F, Winderickx J.
Biochim Biophys Acta. 2008 Oct;1783(10):1767–80.

PUFA induce antidepressant-like effects in parallel to structural and molecular changes in the hippocampus.
Venna VR, Deplanque D, Allet C, Belarbi K, Hamdane M, Bordet R.
Psychoneuroendocrinology. 2009 Feb;34(2):199-211.

Neurogenesis and cell cycle-reactivated neuronal death during pathogenic tau aggregation.
Schindowski K, Belarbi K, Bretteville A, Ando K, Buée L.
Genes Brain Behav. 2008 Feb;7 Suppl 1:92–100.

Neurotrophic factors in Alzheimer's disease: role of axonal transport.
Schindowski K, Belarbi K, Buée L.
Genes Brain Behav. 2008 Feb;7 Suppl 1:43–56. Review.

ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I.
Leroy O, Dhaenens CM, Schraen-Maschke S, Belarbi K, Delacourte A, Andreadis A, Sablonnière B, Buée L, Sergeant N, Caillet-Boudin ML.
J Neurosci Res. 2006 Sep;84(4):852–9.

Neuronal phosphorylated RNA-dependent protein kinase in Creutzfeldt-Jakob disease.
Paquet C, Bose A, Polivka M, Peoc'h K, Brouland JP, Keohane C, Hugon J, Gray F.
J Neuropathol Exp Neurol. 2009 Feb;68(2):190–8.

Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.
Christensen DZ, Kraus SL, Flohr A, Cotel MC, Wirths O, Bayer TA.
Acta Neuropathol. 2008 Dec;116(6):647–55.

Intracellular Abeta triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.
Christensen DZ, Bayer TA, Wirths O.
Neurobiol Aging. 2008 Sep 2.

Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease.
Wirths O, Breyhan H, Marcello A, Cotel MC, Brück W, Bayer TA.
Neurobiol Aging. 2008 doi:10.1016/j.neurobiolaging.2008.06.011

Age-dependent loss of dentate gyrus granule cells in APP/PS1KI mice.
Cotel MC, Bayer TA, Wirths O.
Brain Res. 2008 Jul 30;1222:207–13.

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology.
Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S.
Nat Med. 2008 Oct;14(10):1106–11.

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.
Schilling S, Appl T, Hoffmann T, Cynis H, Schulz K, Jagla W, Friedrich D, Wermann M, Buchholz M, Heiser U, von Hörsten S, Demuth HU.
J Neurochem. 2008 Aug;106(3):1225–36.

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta.
Cynis H, Scheel E, Saido TC, Schilling S, Demuth HU.
Biochemistry. 2008 Jul 15;47(28):7405–13.

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery.
Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S.
J Mol Biol. 2008 Jun 20;379(5):966–80.

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells.
Cynis H, Schilling S, Bodnár M, Hoffmann T, Heiser U, Saido TC, Demuth HU.
Biochim Biophys Acta. 2006 Oct;1764(10):1618–25.

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.
Schilling S, Cynis H, von Bohlen A, Hoffmann T, Wermann M, Heiser U, Buchholz M, Zunkel K, Demuth HU.
Biochemistry. 2005 Oct 11;44(40):13415–24.

Phosphorylation, lipid raft interaction and traffic of alpha-synuclein in a yeast model for Parkinson.
Zabrocki P, Bastiaens I, Delay C, Bammens T, Ghillebert R, Pellens K, De Virgilio C, Van Leuven F, Winderickx J.
Biochim Biophys Acta. 2008 Oct;1783(10):1767–80.

Protein folding diseases and neurodegeneration: lessons learned from yeast.
Winderickx J, Delay C, De Vos A, Klinger H, Pellens K, Vanhelmont T, Van Leuven F, Zabrocki P.
Biochim Biophys Acta. 2008 Jul;1783(7):1381–95.

Protein folding diseases and neurodegeneration: lessons learned from yeast.
Winderickx J, Delay C, De Vos A, Klinger H, Pellens K, Vanhelmont T, Van Leuven F, Zabrocki P.
Biochim Biophys Acta. 2008 Jul;1783(7):1381–95.

Altered splicing of Tau in DM1 is different from the foetal splicing process.
Ghanem D, Tran H, Dhaenens CM, Schraen-Maschke S, Sablonnière B, Buée L, Sergeant N, Caillet-Boudin ML.
FEBS Lett. 2009 Feb 18;583(4):675–9.

Overexpression of MBNL1 fetal isoforms and modified splicing of Tau in the DM1 brain: two individual consequences of CUG trinucleotide repeats.
Dhaenens CM, Schraen-Maschke S, Tran H, Vingtdeux V, Ghanem D, Leroy O, Delplanque J, Vanbrussel E, Delacourte A, Vermersch P, Maurage CA, Gruffat H, Sergeant A, Mahadevan MS, Ishiura S, Buée L, Cooper TA, Caillet-Boudin ML, Charlet-Berguerand N, Sablonnière B, Sergeant N.
Exp Neurol. 2008 Apr;210(2):467–78

Glycogen synthase kinase-3beta, or a link between amyloid and tau pathology?
Muyllaert D, Kremer A, Jaworski T, Borghgraef P, Devijver H, Croes S, Dewachter I,
Van Leuven F.
Genes Brain Behav. 2008 Feb;7 Suppl 1:57–66.

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration.
Muyllaert D, Terwel D, Kremer A, Sennvik K, Borghgraef P, Devijver H, Dewachter I,
Van Leuven F.
Am J Pathol. 2008 Feb;172(2):470–85. /p>

The Na(+)/H (+) exchanger modulates long-term potentiation in rat hippocampal slices.
Rönicke R, Schröder UH, Böhm K, Reymann KG.
Naunyn Schmiedebergs Arch Pharmacol. 2009 Mar;379(3):233–9.

Abeta mediated diminution of MTT reduction--an artefact of single cell culture?
Rönicke R, Klemm A, Meinhardt J, Schröder UH, Fändrich M, Reymann KG.
PLoS ONE. 2008 Sep 18;3(9):e3236.

Microglia cells protect neurons by direct engulfment of invading neutrophil granulocytes: a new mechanism of CNS immune privilege.
Neumann J, Sauerzweig S, Rönicke R, Gunzer F, Dinkel K, Ullrich O, Gunzer M, Reymann KG.
J Neurosci. 2008 Jun 4;28(23):5965–75.